Haemodynamics and myocardial function after sotalol.
نویسندگان
چکیده
may occur (Nakano and Kusakari, I966; Blinks, I967). Sotalol (M.J., i999)l has been reported to be a beta-adrenergic blocking agent devoid of significant myocardial depression (Lish, Weikel, and Dungan, 1965; Levy and Richards, I965). Though studies of sotalol in man have been reported (Brooks et al., 1970; Svedmyr, Malmberg, and Haggendal, I970), little is known of the effect of this drug on myocardial contractility in patients with heart disease. The purpose of the present study was to assess the cardiovascular effects of sotalol with particular reference to myocardial contractility.
منابع مشابه
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I read with interest the article by Plewan et al. that compared head-tohead the efficacy of sotalol vs bisoprolol in the maintenance of sinus rhythm after electrical cardioversion of persistent atrial fibrillation. Their study failed to show any benefit of sotalol over bisoprolol during a follow-up period of 1 year, and showed more adverse effects with sotalol, principally due to proarrhythmia....
متن کاملPrevention of ventricular fibrillation by dextrorotatory sotalol in a conscious canine model of sudden coronary death.
The antiarrhythmic and antifibrillatory actions of the dextrorotatory isomer of sotalol, administered in a multiple-dose regimen, were evaluated in conscious dogs 3 to 5 days after anterior myocardial infarction. The intravenous administration of d-sotalol, four 8 mg/kg doses over a 24-hour treatment period, suppressed the induction of ventricular tachycardia by programmed electrical stimulatio...
متن کاملComparison of sotalol with amiodarone for long-term treatment of spontaneous sustained ventricular tachyarrhythmia based on coronary artery disease.
AIM To compare the efficacy of sotalol versus amiodarone for long-term treatment of ventricular tachyarrhythmias. METHODS Patients (n=75) with spontaneous, sustained ventricular tachyarrhythmias secondary to remote myocardial infarction were studied. After intravenous electrophysiological testing, both sotalol and amiodarone were predicted to be ineffective in 50 (67%) patients. Five patients...
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Sotalol is a beta-adrenergic blocker that also prolongs action potential duration and myocardial refractoriness over the short term (class III effect). Its short-term antiarrhythmic effects were compared with those of metoprolol, which has neither short-term class III nor membrane-stabilizing action, on reentrant ventricular arrhythmias produced by programmed stimulation in 17 conscious dogs 3 ...
متن کاملManagement and outcome of patients with atrial fibrillation during acute myocardial infarction: the GUSTO-III experience. Global use of strategies to open occluded coronary arteries.
OBJECTIVE To investigate the use of antiarrhythmic agents and electrical cardioversion in the management of patients with atrial fibrillation complicating acute myocardial infarction, and their relation to 30 day and one year mortality. DESIGN Prospective study of 1138 patients with atrial fibrillation from the GUSTO-III trial. INTERVENTIONS Of the 1138 study patients, 317 (28%) received an...
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ورودعنوان ژورنال:
- British heart journal
دوره 34 8 شماره
صفحات -
تاریخ انتشار 1972